Homogeneous and stable (+)-usnic acid loaded liposomes prepared by compressed CO2

The administration of hydrophobic actives and drugs for medical or cosmetical purposes generally requires a formulation that ensures adequate water solubility, which can be achieved through the encapsulation in liposomes. For vehiculation (+)-usnic acid (UA), compound with antioxidant activity, we have prepared liposomes one-step process using compressed CO2. investigated formulations are mainly composed 1,2-dimyristoyl-sn-glycero-3-phosphocholine cholesterol, but contain also small molar fraction (10%) synthetic surfactant derived from L-prolinol. In previous investigations containing L-prolinol derivatives showed higher efficacy as DNA drug delivery systems respect to mere phospholipids. As consequence, they were added make them more suitable UA systems. By testing different chain lengths headgroups, studied how chemical nature affects physicochemical vesicle properties their interaction UA. Most formulations, especially those surfactants longer alkyl chains (C14 C16), show good potentiality because exhibit stability, vesicle-to-vesicle homogeneity bilayer compaction analog by conventional thin film hydration previously investigated. Our results confirm advantages DELOS-SUSP case mixed phospholipids ionic surfactants. Moreover, this study demonstrates same lipids feature if according methodologies. addition, investigation points out solute included affected technique used preparation.